Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization
نویسندگان
چکیده
منابع مشابه
Kv3.1 uses a timely resurgent K+ current to secure action potential repolarization
High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system. Voltage-dependent Kv3 channels play an important role in this process thanks to their high activation threshold and fast closure kinetics, which reduce the neuron's refractory period. However, premature Kv3 channel closure leads to incomplete membrane repolarization, pr...
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Voltage-dependent sodium channels were studied in dissociated cerebellar Purkinje neurons from rats. In whole-cell recordings, a tetrodotoxin (TTX)-sensitive inward current was elicited when the membrane was repolarized to voltages between -60 and -20 mV after depolarizations to +30 mV long enough to produce maximal inactivation. At -40 mV, this "resurgent" current peaked in 8 msec and decayed ...
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KEY POINTS Auditory brainstem neurons of all vertebrates fire phase-locked action potentials (APs) at high rates with remarkable fidelity, a process controlled by specialized anatomical and biophysical properties. This is especially true in the avian nucleus magnocellularis (NM) - the analogue of the mammalian anteroventral cochlear nucleus. In addition to high voltage-activated potassium (KHVA...
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OBJECTIVE It is unknown whether 4-aminopyridine- (4-AP-) sensitive transient outward K(+) current (I(to1)) and/or Ca(2+)-activated transient outward Cl(-) current (I(Ca.Cl) or I(to2)) contribute(s) to phase 1 repolarization of pig ventricular action potential (AP). The purpose of the present study was to determine ionic contribution of the phase 1 repolarization of AP in pig ventricle. METHOD...
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KChAP: a novel chaperone for specific K ϩ channels key to repolarization of the cardiac action potential. Focus on ''KChAP as a chaperone for specific K ϩ channels'' THE BIOSYNTHESIS OF ION CHANNELS is complex, and its tight regulation occurs at different levels, i.e., gene expression, transcription, as well as pre-and posttran-scriptional processing (7). During the last 10 years, emphasis has ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2015
ISSN: 2041-1723
DOI: 10.1038/ncomms10173